Joseph Grzybowski

RESEARCH INTERESTS. My students and I have been investigating clathrochelate complexes, species in which the metal ion is completely encapsulated in a ligand cage. We have been designing clathrochelate complexes which possess functional groups that allow these cage complexes to be bonded together or be bonded to other metal complexes. Our main area of focus recently has been the synthesis of porphyrin species with appended clathrochelates, the self-assembly of molecular squares that contain clathrochelate complexes, and the exploration of new synthetic routes to form linked clathrochelate complexes.


"Reversible-Irreversible Approach to Schff Base Macrocycles: Access to Isomeric Macrocycles with Multiple Salphen Pockets." P. D. Frischmann, J. Jiang, J. K.-H. Hui, J. J. Grzybowski, M. J. MacLachlan. Organic Letters, 2008, 10, 1255.

"Chemical and Coliform Bacterial Analysis of Springs and Creeks in Adams County, Pennsylvania." P. P. Fong, J. J. Grzybowski, E. N. Barkdoll. Journal of PA Acad. of Sci. 2006, 80, 4.

"Synthesis of a Clathrochelate Complex with an Appended Pyridine and Its Coordination to a Cobaloxime Complex," C. Engtrakul, W. J. Shoemaker, J. J. Grzybowski, I. Guzei, A. Rheingold, Inorg. Chem. 2000, 39, 5161.


"Ferrocenium Trifuoroborate, An Unexpected Product” Paul F. Smith and Joseph J. Grzybowski. Presented at the 41st Middle Atlantic Regional meeting of the American Chemical Society, Wilmington, DE (April 11, 2010)

"Metal Ions in Cages. A Look at Clathrochelate Chemistry," Joseph Grzybowski. Presented at the University of British Columbia, Vancouver, BC (November 1, 2006)

"Molecular Squares with Clathrochelate Complexes as Edge Pieces," Tina L. Tao, C. Adam Samuelson, and Joseph J. Grzybowski. Presented at the 228th National Meeting of the American Chemical Society, Philadelphia, PA (August 24, 2004).

"Synthesis and Characterization of Porphyrins with Appended Clathrochelate Complexes," Joseph J. Grzybowski, Alanya M. Engtrakul, Melissa L. Cook, and Anthony J. DeFail. Presented at the 220th National Meeting of the American Chemical Society, Washington, DC (August 20, 2000)


“Don’t Be So Negative! Shifting the Redox Potential of Cobalt Clathrohelate Complexes,” Minh An T. Nguyen and Joseph Grzybowski. Presented at the 76th Intercollegiate Student Chemists’ Convention, Bloomsburg University, April 14, 2012.

"The Synthesis and Characterization of a Porphyrin with Appended Clathrochelate Complexes," Adam Rinker and Joseph Grzybowski. Presented at the 70th Intercollegiate Student Chemists' Convention, Ursinus College, April 22, 2006.


Joseph Grzybowski

Joseph Grzybowski
Professor, Chemistry

Phone: (717) 337 - 6255

Box: Campus Box 0393

Address: Science Center
Room 361
300 North Washington St.
Gettysburg, PA 17325-1400

BS King's College, 1972
PhD Case Western Reserve University, 1977