Nanoscale materials such as gold and silver demonstrate unique optical properties that can be harnessed for applications in drug delivery, photothermal therapeutics, sensing and imaging. Gold nanoparticles are probably one of the most well known classes of nanomaterials in existence, yet there is still much to learn about their synthesis, growth, and self-assembly. Research in the NanoLab strives to gain a fundamental understanding of how the chemistry at the interface of the nanoparticles influences their behavior. Our studies range from the electrostatics and thermodynamics of polymer adsorption to the environmental fate and consequence of nanoparticles. This work is highly interdisciplinary in nature that requires collaboration across the Chemistry, Biology, and Physics Departments.
Please check out some of our recent work in the publications listed below.
1. Thompson, L. B., Carfagno, G. L.F., Andresen, K., Sitton, A. J.*, Bury, T.*, Lee, L. L.*, Lerner, K. T.* and Fong, P. P. Differential uptake of gold nanoparticles by two species of tadpole, the wood frog (Lithobates sylvaticus) and the bullfrog (Lithobates catesbeianus) Environ Tox. Chem. Accepted Author Manuscript. doi:10.1002/etc.3909
2. Fong, P.P.; Thompson, L.B.; Carfagno, G.L.F.; Sitton, A.J.* Chronic, long-term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations. Environ. Tox. Chem. 2016, 35, 2304–2310
3. Alkilany, A.M.; Caravana, A.C.*; Hamaly, M.A.; Lerner, K.T.*; Thompson, L.B. Phase Transfer of Citrate Stabilized Gold Nanoparticles Using Nonspecifically Adsorbed Polymers. J. Colloid. Interface Sci. 2016, 461, 39-44.
4. Alkilany, A. M.; Boulos, S. P.; Lohse, S. E.; Thompson, L. B.; Murphy, C. J. Homing Peptide-Conjugated Gold Nanorods: the Effect of Amino Acid Sequence Display on Nanorod Uptake and Cellular Proliferation. Bioconjugate Chemistry 2014, 25, 1162–1171.
*Denotes Gettysburg College Student
Lucas B. Thompson
Associate Professor, Chemistry
Phone: (717) 337 - 6294
Box: Campus Box 0393
300 North Washington St.
Gettysburg, PA 17325-1400
BA The College of Wooster, 2003
PhD The University of Illinois at Urbana-Champaign, 2009
Nanoparticle synthesis and processing, chemical modifications of nanostructured and planar surfaces