BIO-101 Basic Biological Concepts
Course covers basic topics in cell biology, bioenergetics, gene expression, and patterns of inheritance with a focus on important topical issues. Designed for nonscience majors. Laboratory emphasizes the experimental nature of biological investigation. Three class hours and laboratory. Students may not receive credit for both BIO 101 and BIO 110.
BIO-102 Contemporary Topics in Biology: Biological Basis of Disease
Designed for nonscience majors. Course covers selected biological topics related to human diseases and focuses on contemporary problems and their possible solutions. Three class hours and laboratory.
BIO-103 Contemporary Topics in Biology: Plants and Society
Designed for nonscience majors. Course covers selected biological topics related to the importance of plants to humans.
BIO-110 Introductory Biology: Molecules, Genes & Cells
Introduction to cell biology, bioenergetics, gene expression, and patterns of inheritance with a focus on important topical issues. Laboratory emphasizes the experimental nature of biological investigation. Students not majoring in biology but who are interested in the health professions may, with a grade of C- or better in Biology 110, enroll in Biology 112. Three class hours and laboratory. Students may not receive credit for both BIO 101 and BIO 110.
BIO-111 Introduction To Ecology and Evolution
Designed to introduce students to general biological principles, with a focus on ecology and evolution. Topics include adaptation, nutrient cycling and energy flow, population growth and species interactions, Mendelian and population genetics, speciation, and the history of life. Laboratory emphasizes the experimental nature of biological investigation. Designed for science majors with a high school background in biology, chemistry, and mathematics. Three class hours and laboratory.
BIO-112 Form and Function in Living Organisms
Designed for science majors. Morphology and physiology of plants and animals are emphasized. Lecture and laboratory topics include nutrition, energetics, internal regulation, neural and hormonal integration, and reproduction. Prerequisite: Bio 111, or 101 (prior to Fall 11), Bio 110 (starting Fall 11), with a C- or better. Three class hours and laboratory.
BIO-113 Introduction to Phage Biology
Designed to introduce potential science majors to general biological principles – cell biology, gene expression, inheritance, ecology and evolution. Laboratory emphasizes the experimental nature of biological investigation using the biology of viruses (bacteriophages) and their bacterial hosts as a model. Six lecture/laboratory hours, and two discussion hours.
BIO-114 Phage Genomics
Covers basic topics in genome science, focusing on describing and annotating a newly sequenced phage genome obtained by students in the previous fall semester. Designed for science majors. Laboratory emphasizes the experimental nature of biological investigation. Three lecture/computer laboratory class hours. Pre-requisite Bio 113.
BIO-115 First Year Research
One-semester research experience for first-year students. This course alternates between two different topics, one that is lab-based, and the other, which is a combination of lab- and field-work. On even-numbered years students will investigate mechanisms that protect DNA and the cancer-enabling properties of cells in which critical cancer-protective proteins are missing, with a view to understanding “why normal cells get it right every time they divide, and why cancer cells get it wrong every time they divide”. Projects use techniques of genetics, molecular biology, and genetic engineering to investigate how genome instability, marked by loss of cell cycle control and impairment of DNA repair, accelerates cancer progression. On odd-numbered years students will investigate the startling global declines of amphibians (salamanders, frogs, and caecilians). Projects will include work on limb deformities, estrogenic compounds, ecosystem services, emerging infectious diseases, and species "arks." Students will learn techniques in experimental design, modeling, field sampling, histology, quantitative PCR, and project-specific methodologies (e.g. diet analysis, GIS, etc.).
BIO-118 The Chemistry of Life
Taught in coordination with CHEM 118, this class covers the fundamental principles of chemical reactivity and explores how those principles enlighten our understanding of modern biological processes, with an emphasis on the physiological function of the major organ systems. Both lectures and labs integrate chemistry and biology to convey a holistic view of how these subjects interrelate to resolve current questions in science. Prerequisites: BIO 110 or 111 or 113, with a grade of C- or better; and CHEM 105 or CHEM 107; and concurrent enrollment in CHEM 118. Equivalent to BIO 112.
BIO-202 Structural Plant Development
Anatomical approach to the study of higher plant structures. The origin and differentiation of tissues and organs, environmental aspects of development, and plant anomalies are studied. Six hours in class-laboratory work.
BIO-204 Biology of Flowering Plants
Identification, classification, structural diversity, ecology, and evolutionary relationships of the angiosperms. Course includes field work for collection and identification of local flora. Three class hours and laboratory-field work.
Principles of ecology, with emphasis on three levels of the biological hierarchy-organisms, populations, and communities-that are needed to understand the factors that determine the abundance and distribution of any species. Course includes a number of field trips. Three class hours and laboratory-field work. Credit cannot be received for both this course and Environmental Studies 211.
BIO-206 Physiological Ecology
Exploration of environmental effects on fundamental physiological processes and adaptations used by animals to cope with both abiotic factors such as temperature and water availability and biotic forces such as herbivory, predation and competition. Factors determining the distribution and abundance of animals will also be discussed. The history of studies in physiology and ecology will be introduced. Prerequisite: BIO 111 & 112 (grade of C or better in each course) AND permission of instructor. BIO 110 is an acceptable pre-requisite for students who also have completed an Ecology course such as ES 211
Overview of principles of genetics. Topics include chemical nature of genes, Mendelian and non-Mendelian inheritance, gene regulation, genetic engineering, molecular evolution, and population genetics. Three class hours and laboratory. Prerequisite: Bio 112 with a grade of C- or better and Chem 107.
BIO-212 Cell Biology
Structure and function of eukaryotic cells. Topics include protein structure, enzyme function, membrane structure and transport, protein sorting, energy transduction by mitochondria and chloroplasts, chromosome structure, cell division and cell-cycle control, cell communication, cell motility, and cell biology of cancer. Three class hours and laboratory. Prerequisite: Bio 112 and Chem 108 with a grade of C- or better in both courses.
BIO-217 An Evolutionary Survey of the Plant Kingdom
Synopsis of embryo-producing plants, primarily liverworts, mosses, fern allies, ferns, and seed plants. Emphasis is on comparative morphology or vegetative and reproductive characters, unique features, and evolutionary trends in plants. Six hours in class-laboratory work.
Exploration of common themes in symbiotic associations between organisms, techniques used to investigate these relationships, and future trends of this increasingly important field of biology. Topics include components of animal behavior, development, genomics, evolution, and ecology. Primarily a lecture format although will also include in-class demonstrations and projects. These projects will occasionally require a greater time commitment than the scheduled class meetings. Prerequisite: Biology 112. Counts as an Organismal course within the BIO major.
BIO-224 Vertebrate Zoology
Introduction to systematics, distribution, reproduction, and population dynamics of vertebrates. Field and laboratory emphasis on natural history, collection, and identification. Optional trip to North Carolina. Six hours in class, laboratory, and field work.
BIO-225 Animal Behavior
Study of animal behavior through readings, discussions, and field and laboratory observations. Phenomena considered range from simple reflex response to complex social organization. Role of behavioral adaptations in the biology of animal species is emphasized. Three class hours and laboratory.
BIO-227 Invertebrate Zoology
Study of the structure, physiology, and behavior of the major groups of animals representing 99 percent of the animal kingdom. Focus is on functional morphology and evolutionary adaptation. Course includes individual or group research projects. Six hours in class-laboratory work.
BIO-228 Tropical Marine Biology
Biology of tropical marine organisms and study of the geological, chemical and physical processes in tropical marine ecosystems. Course requires a 2-week summer field/lab program at a marine research station in the Bahamas (additional costs). In the field, the students snorkel to observe diverse marine organisms in habitats such as coral reefs and rocky/sandy intertidal zones. Prerequisite: Permission of the instructor.
BIO-229 Tropical Terrestrial Biology
This course familiarizes students with current and relevant topics in tropical biology. Students learn major concepts in tropical biodiversity, community ecology, and conservation and discuss current research advances in these areas. Students also develop an appreciation for the diversity of life and the processes than contribute to this diversity. This course combines a lecture/seminar section during the Spring semester with a lab section/field trip to Manu National Park in Perú, at the beginning of the summer break. Prerequisite: Bio 111, BIO 112 and permission of the instructor
Biology of viruses and bacteria, with emphasis on morphology, metabolism, taxonomy, reproduction, and ecology. Laboratory includes isolation, culture, environmental influences, identification, and biochemical characterization of bacteria and their viruses. Three class hours and laboratory.
Paleobiology. Diversity, biology and ecology of ancient life; the major biological and geological changes that had a significant impact on our evolutionary history and the key geological and physical processes that shaped our earth during its 4.5 billion year history. Laboratory component introduces students to the techniques required for the proper collection, preservation, identification and cataloging of fossils; and involves visits to local fossil collection sites and museums. Students are required to develop a personal fossil collection during this course.
BIO-251 Introduction to Bioinformatics
Introduction to the emerging field of bioinformatics, where biology and computer science intersect to interpret and use the rapidly expanding volume of biological information produced by genome sequencing and proteomic exploration of life processes. Application of bioinformatic software tools to the analysis of gene sequences and protein structures is emphasized. Students undertake a laboratory project combining in silico and in vitro approaches to isolate and then analyze a segment of their own DNA. An introduction to computer algorithms used in bioinformatic software is provided. Three class hours and laboratory. Biology 251 and CS 251 are cross-listed.
Designed for students in biology who plan to engage in individualized study and/or research. Topics include the nature of biological data and the statistical procedures to analyze them. Special attention given to experimental design and hypothesis testing. Three class hours and one hour discussion. Credit cannot be received for both this course and Health Science 232, Mathematics 107, Psychology 205, or Economics 241.
BIO-290 Mentored Research Internship
Quarter credit internship graded S/U.
BIO-306 Marine Ecology
Analysis of the ecology of marine systems. The open ocean, estuaries, salt marshes, beaches, mud and sand flats, seagrass beds, rocky shores, coral reefs, and deep sea are examined. Problems of pollution, beach erosion, and the management of declining fisheries is also presented. Quantitative field work in a variety of coastal habitats is conducted on a required field trip to Duke University Marine Laboratory and the Outer Banks barrier island chain. Three class hours and laboratory-field work. Alternate years. Prerequisite: ES 211.
BIO-307 Freshwater Biology
Study of the physical, chemical, and biological characteristics of inland waters. Topics include nutrient cycling, biological interactions, and effects of human activities. Course includes individual research projects and a number of field trips. Six hours in class, laboratory, and field work. Capstone Course. Prerequisite: Junior or Senior Standing.
Study of the transformation and diversification of populations through time. Topics include history of life, adaptation, selection and population genetics, speciation and extinction, evolutionary innovations, and patterns of diversity. Three class hours and laboratory. Capstone course. Prerequisite: Bio 211.
BIO-315 Molecular and Genome Evolution
The study of the factors that shape the evolution of genes and genomes. The organization, origin, and mechanisms of change of viral, prokaryotic and eukaryotic genomes are explored. Topics include: structure and function of genes, chromosomes, and genomes; the roles of natural selection and chance as drivers of molecular evolution; rates and patterns of DNA and amino acid sequence evolution; molecular phylogeny; reticulate evolution; gene duplication and mobile elements; genome evolution. Prerequisite: BIO 211
BIO-316 Conservation Biology
A discipline comprising pure and applied science, which focuses on the preservation of biological diversity. Focus implicitly recognizes that preserving the genetic and ecological features of a species requires preservation of that species' niche. Topics include food web organization, spatial heterogeneity and disturbance, consequences of small population size and inbreeding, captive propagation, demographics of population growth, and species reintroduction and management. Prerequisite: Environmental Studies 211 or BIO 111. BIO 316 and ES 316 are cross-listed.
BIO-320 Development Biology
Survey of the phenomena and principles of animal development. Major attention is given to the genetic and cellular mechanisms that control cell differentiation and the development of form in several model organisms. Vertebrates are emphasized in the study of organ development. Three class hours and laboratory. Capstone course. Prerequisite: Bio 211 and 212.
BIO-330 Microbial Pathogenesis
Will explore the various strategies employed by microbial pathogens and will focus on the molecular mechanisms of virulence, gene regulation, pathogenesis, host-pathogen interactions and epidemiology. Prerequisite: BIO 230 Microbiology or permission of instructor
Introduction to the vertebrate immune system at the molecular, cellular, and organismal levels. Antibody structure, antigen-antibody interaction, the genetics of antibody diversity, the immune response, and the bases of self/non-self discrimination are emphasized. Three class hours. Prerequisite: Bio 211 and Bio 212.
BIO-334 Biochemistry II
Detailed survey of the primary and secondary metabolic processes in living cells. Topics discussed include the overall organization of metabolic pathways, carbohydrate and fatty acid metabolism, biological oxidation and reduction and energy production. Special attention is given to regulation, hormone action, metabolic disorders and disease. Laboratory work includes an independent research project. Three lecture hours and one laboratory afternoon. Capstone course for Biology majors. Prerequisite: Biology majors- Bio 212 and Chem 204, or permission of the instructor.
An exploration of the biological basis of brain function, including: electrical and chemical signaling of nerve cells; modulation and plasticity of signaling occurring in different behavioral states or during learning; and the structure, function, and development of circuits of interconnected nerve cells involved in sensory perception and motor coordination. Emphasis is placed on the behavioral and clinical aspects of modern neurobiology: how particular properties of the brain underlie specific behaviors, and how malfunctions of neural mechanisms lead to various neurological disorders. Capstone course for Biology majors. Prerequisite: Bio 212 with a C- or better or Bio 112 and Psych 236 both with a C- or better.
BIO-340 Comparative Animal Physiology
Regulation of basic physiological processes in animals. Unifying principles are studied using a comparative approach. Three class hours and laboratory. Credit cannot be received for both this course and HS 210. Prerequisite: grade of C or better in Bio 212.
BIO-351 Molecular Genetics
Study of the basic mechanisms of information storage and retrieval from DNA and RNA. Topics include genome organization and the regulation of gene expression in prokaryotes and eukaryotes; DNA replication and repair; molecular genetics of cancer and human-inherited disorders; and recombinant DNA technology. Three class hours and laboratory. Capstone course. Prerequisite: Bio 211 and 212.
BIO-359 X-lab: Drugs and Cells
Combined upper-level biology/chemistry/health sciences laboratory where students design and synthesize organic compounds and determine the impact of structural modifications on these compounds’ biological activity. The semester is divided into two parts: the synthesis, isolation, and characterization of a derivative of a known, biologically active organic compound; and the assessment of its effect on cellular biology in vitro.
BIO-361 Evolutionary Medicine
Study of the application of evolutionary thinking to human health issues. Topics to be covered include evolution of pathogens and virulence; mal-adaptations to modern lifestyles; genetic conflicts associated with reproduction including pregnancy; evolution of aging and age-related diseases. Seminar will address if and when medical treatment or public health policies benefit from incorporating an evolutionary perspective. Prerequisite: Bio 211 and Bio 212.
BIO-390 Ecology, Evolution, and Molecular Biology of Viruses
Viruses are the most diverse group of organisms on the planet. This course will introduce students to this diversity with respect to both virus structure and virus/host interactions. In addition it will integrate this systematic knowledge with an understanding of the processes that generate and maintain viral diversity. The laboratory component of the course will introduce students to the techniques required for the isolation and culture of viruses in the laboratory, the visualization of viruses via transmission electron microscopy, and the bioinformatic analysis of viral nucleic acid sequences. Prerequisite: Bio 211 and Bio 212.
BIO-450 Individualized Study-Tutorial
Individualized tutorial counting toward the minimum requirements in a major or minor, graded A-F
BIO-451 Individualized Study-Tutorial
Individualized tutorial counting toward the minimum requirements in a major or minor, graded S/U
BIO-452 Individualized Study-Tutorial
Individualized tutorial not counting in the minimum requirements in a major or minor, graded A-F
BIO-453 Individualized Study-Tutorial
Independent investigation of a topic of special interest, directed by a faculty member familiar with the general field of study. May be used as preparation for enrollment in Biology 460. Prerequisite: Approval of directing faculty member.
BIO-460 Individualized Study-Research
Independent investigation of a topic of special interest, normally including both literature and laboratory research. Directed by a faculty member. Results of investigation are presented to the department. Open to juniors and seniors. Capstone course Prerequisite: Approval of both the directing faculty member and department.
BIO-461 Individualized Study-Research
Individualized research counting toward the minimum requirements in a major or minor, graded S/U Capstone course
BIO-462 Individualized Study-Research
Individualized research not counting in the minimum requirements in a major or minor, graded A-F
BIO-463 Individualized Study-Research
Individualized research not counting in the minimum requirements in a major or minor graded S/U
BIO-470 Individualized Study-Internship
Internship counting toward the minimum requirements in a major or minor, graded A-F
BIO-471 Individualized Study-Internship
Internship counting toward the minimum requirements in a major or minor, graded S/U
BIO-472 Individualized Study-Intern
Internship not counting in the minimum requirements in a major or minor, graded A-F
BIO-473 Individualized Study-Intern
Independent internship experience under the direct supervision of professional personnel in a variety of biology-related areas. Internship may be arranged by the department or the student. Must combine practical work experience with an academic dimension. Library research paper on a subject related to the experience is required. Prerequisite: Approval of both supervisor and department. Contact Center for Career Development for application and further assistance.
BIO-474 Summer Internship
Summer Internship graded A-F, counting in the minimum requirements for a major or minor only with written permission filed in the Registrar's Office.
BIO-475 Summer Internship
Summer Internship graded S/U, counting in the minimum requirements for a major or minor only with written permission filed in the Registrar's Office
BIO-477 Half Credit Internship
Half credit internship, graded S/U.