Biology

Lauren Klabonski

Visiting Assistant Professor

Biology

Contact

Box

Campus Box 0392

Address

McCreary Hall

300 North Washington St.
Gettysburg, PA 17325-1400

Education

PhD Biological Sciences, Drexel University, 2019
BS Biology, Penn State University, 2011

Academic Focus

Protein sorting and trafficking, neuroendocrine signaling, cell specificity

Growth factors are secreted proteins with well-studied roles in development, differentiation, metabolism, and many other cellular processes. Local secretion of growth factors such as transforming growth factor beta (TGF-β) from neurons in the brain has also been shown to ameliorate aspects of neuronal dysfunction in patients with neurodegenerative diseases, like Alzheimer’s and Parkinson’s disease. While targeting TGF-β biogenesis may be a potential avenue for neurodegenerative disease therapeutics, there is not much known about the mechanisms governing TGF-β synthesis and secretion from neurons. We are using the nematode worm Caenorhabditis elegans, to study in vivo biogenesis and neuronal secretion of TGF-β-like protein called DAF-7 and, hopefully, gain insight into these mechanisms.

Courses Taught